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POLG, Polymerase gamma

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Moreover, tumor-derived EVs transfer tumor-associated antigens to DCs, which subsequently initiate tumor-specific cytotoxic T lymphocytes (CTLs) and induce effective antitumor immune responses [64]

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In fact, the accumulation of dysfunctional mitochondria is characteristic of aging, with decreased ATP production and increased ROS generation [10,11]

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Mitochondrial ROS regulation of proliferating cells

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doi: 10.3389/fimmu.2017.01239

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