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Comprehensive biochemical testing demonstrates that 5 amino 1mq does not inhibit structurally similar methyltransferases, including catechol-O-methyltransferase (COMT), DNA methyltransferase 1 (DNMT1), or protein arginine methyltransferase 3 (PRMT3)

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If Ca2+-free solution was applied in the recording pipette, no apamin-sensitive current was detected (Figure S2 D-F), confirming existence of currents conducted by SK1-3 channels (I SK1-3 )

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