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By comparison, those who made lifestyle changes alone lost only about 2.4% of their weight [3]

.,MiyataY,MatsuoT,MitsunariK,AsaiA,OhbaKSakaiHA review of oxidative stress and urinary dysfunction caused by bladder outlet obstruction and treatments using antioxidants.2019;8(5):132 88

Not only disruption of the clock genes but also chronic circadian disruption or/and ablation of crucial metabolic transcriptional co-regulators such as SRC-2 (Steroid Receptor Coactivator-2) can affect metabolic homeostasis

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Role of NRF2 and KEAP1 in the regulation of GSH abundance NRF2 is regarded as a major contributor to cell survival and redox balance and is regulated by KEAP1, an adapter protein of Cullin 3 (Cul3) containing E3 ubiquitin ligases