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Meidenbauer JJ, Ta N, Seyfried TN

Reacting to our concerns about the alternative oral treatment the new guideline states clearly that if patients experience any neurological symptoms numbness or pins and needles then he or she must contact their GP immediately

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(see section on 2,3-BPG deficiency)

However, chronic exposure to alcohol may elevate glutamate levels, which can lead to withdrawal-associated effects of alcohol deprivation and exposure subject's seeking alcohol-associated negative reinforcement to remove the same (Valenzuela, 1997)

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