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Research indicates that patients with impaired kidney function, including premature neonates, who receive parenteral levels of aluminum at greater than 4 to 5 mcg/kg/day accumulate aluminum at levels associated with central nervous system and bone toxicity

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ERR agonism (SLU-PP-332): investigated as a synthetic pan-ERR (estrogen-related receptor) agonist studied for its effects on mitochondrial gene expression and oxidative metabolism, a mechanism central to exercise-mimetic research

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