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This Zn-glutamate crosstalk extends to transporter modulation: Zn 2+ inhibits excitatory amino acid transporter-1 (EAAT-1) and GABA_A receptors, while Pb 2+ downregulates astrocytic GLT-1 and neuronal EAAC1, collectively impairing glutamate clearance (125127)

Weight loss fundamentally requires a sustained caloric deficitconsuming fewer calories than the body expendsalongside behavioural, dietary, and often physical activity modifications

Arabidopsis thaliana expresses a second functional phytochelatin synthase

NRF2 activity also has a suppressive effect on the Stimulator of Interferon Genes (STING) pathway

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The findings suggest that TFPs are promising natural bioactive compounds with potential applications in disease prevention and treatment, and they represent valuable candidates for the development of functional foods and therapeutic agents