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These results were combined with antitumor activity and/or disease stabilization in patients with various advanced malignancies (Brown et al ., 2001

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EV1C) that like Rv1127c, are essential for the metabolism of cholesterol and propionate (Griffin et al, 2012), suggesting that Rv1127c may perform an unexpected role in the MCC

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Although MTX has a relatively high bioavailability (6490%), it varies significantly among patients and reaches a plateau at doses beyond 15 mg/week, suggesting intestinal transporter saturation (Hillson and Furst 1997