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In addition, orofacial nerve injury (IONI) induced neuropathic pain can up-regulate the IGF-1, while subcutaneous injection of IGF-1 neutralizing antibody can recover the mechanical head withdrawal reflex thresholds (MHWTs) significantly[76]

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Introduction Alpha-lipoic acid (ALA), IUPAC name: 5-(1,2-dithiolan-3-yl) pentanoic acid, is a natural compound endowing different beneficial effects for health

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TUMOR IMMUNE MICROENVIRONMENT Recent studies have suggested that targeting dysregulated cancer metabolism and the metabolic interplay of cancer cells, TME, and cancer stem cells can overcome therapeutic resistance [20]