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Collectively, these advances shift the focus from BBB penetration alone to a holistic framework linking transport, distribution, pharmacodynamics, and safety

FIGURE 2 Mechanical stress induced by increased IOP in glaucoma results in increased EGF receptor expression following astrocyte activation, as well as increased levels of TNF-, matrix metalloproteinases (MMPs), endothelins, and nitric oxide synthase 2 (NOS-2), ultimately leading to a neurodegenerative response (Liddelow et al., 2017

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In the absence of the inflammasome, bacteriolysis instead activates the DNA sensor cGAS, causing type I interferon (IFN-I) production 43