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AMEERA-3: randomized phase II study of amcenestrant (oral selective estrogen receptor degrader) versus standard endocrine monotherapy in estrogen receptor-positive, human epidermal growth factor receptor 2-negative advanced breast cancer
Phase 1 study dosing: Doses tested: 100 mcg to 1000 mcg daily Route: subcutaneous injection Results: dose-proportional effects on fat loss Safety: all doses well tolerated Phase 2 study dosing: Doses tested: 300 mcg to 600 mcg daily Route: once- or twice-daily subcutaneous injection Duration: 12 weeks typical Results: significant fat loss at all doses, with 500600 mcg showing the best efficacy Research Dosage Guidelines Based on available clinical data, research protocols generally consider the following ranges

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is a cofounder of Agios Pharmaceuticals and a member of the board of directors of Merck and Charles River Laboratories
