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Thioredoxin (Trx): a redox target and modulator of cellular senescence and aging-related diseases

Briefly, whole brain of newborn rats (postnatal days 57) was dissected and placed in ice-cold Ca 2+ -free dissection solution (10 mM D-glucose, 4 mM KCl, 26 mM NaHCO 3 , 8% sucrose, 5 mM MgCl 2 , 1:1000 Phenol Red) saturated with 5% CO 2 /95% O 2 , enabling the brain to chill for 1 min

2.3.5 Peripheral blood mononuclear cell extraction For peripheral blood mononuclear cell (PBMC) extraction, 3 mL of blood was collected in EDTA-coated tubes and stored at 4 C

Detoxification Support: Plays a critical role in phase II liver detoxification by binding to toxins, heavy metals, and metabolic waste for safe elimination

It showed significant induction of mitochondrial dysfunction and loss of mitochondrial membrane permeability by modulating Bcl2/Bax proteins, and also caspase activation [89]

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