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This introduces additional variability that can obscure the therapeutic signal of a novel compound

When comparing these results at different ages, we noticed that cytokine concentration was increasing with age, with IL-1, IL-10, IFN, and TNF being the most highly secreted in the bone marrow

By modulating oxidative stress and mitochondrial integrity, AST indirectly influences -synuclein clearance mechanisms, potentially limiting the formation of Lewy bodies (Paramakrishnan et al., 2023)

[DOI] [PubMed] [Google Scholar] 496.Tournissac M, Chaigneau E, Pfister S, Aydin A-K, Goulam Houssen Y, OHerron P, Filosa J, Collot M, Joutel A, Charpak S

Although several drugs are prescribed for these disorders, some are not able to cross the bloodbrain barrier (BBB), and their efficacy in treated ND is limited