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Due to a time lag in the conventional route of administration, there is a possibility that an active compound may become a slow-acting molecule that may be destroyed once it gets inside the brain tissue or enzyme catalytic activity rendering it useless [183]

Kanehisa, M., Goto, S., Sato, Y., Kawashima, M., Furumichi, M., & Tanabe, M

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Alternatively, ozone therapy (minus the UBI component) can also be administered via insufflation

Moreover, hydrochloric acid (HCl) that is also present in the stomach may change clinoptilolite physical chemical properties and has been proven to enhance the clinoptilolite ion-exchange capacity for Cu 2+ and Co 2+ in a synthetic Cu-Co solution at concentrations relevant for the stomach in vivo (0.1 M) (MambaI et al., 2010)

Pernas, L