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Notwithstanding the strides achieved in genetic manipulation and regenerative technologies, L-DOPA or compounds related to dopamine metabolism such as MAO-B inhibitors remain as the major modes of palliative care for PD patients 39,56

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It suppresses ECM degradation, counteracts RSL3 mediated inhibition of GPX4, increases intracellular GSH levels and the GSH/GSSG ratio, reduces MDA content, and inhibits activation of the MAPK/NF-KB pathways, thereby protecting chondrocytes from ferroptosis (156)

Mechanism of Action ALA is a naturally occurring compound that plays a key role in every human cell and exhibits various pharmacodynamic effects beyond its primary role as an antioxidant [7,14,64,65] (Figure 1)

doi: 10.1073/pnas.81.8.2572
