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In the HCT8/ADR cells that overexpress the mannose receptors, the Man-liposomes altered the intracellular distribution of Dox, resulting in a high accumulation of Dox in the nuclei and thus displaying the highest cytotoxicity (IC50=0.073 g/mL) among all the groups

doi: 10.1210/jc.2006-2527

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Retreived August 13, 2020, from: Paca SP, Neme B, Vlase L, Gagyi CE, Dronca E, Miu AC, Dronca, M

Extra B12 Already in the drip, but a higher dose can take the energy lift even further

Alternatively, the bound-form glutathione may be degraded into amino acids on the cell membrane surface and the resulting amino acids may be incorporated into the hepatocytes and then used for intracellular glutathione synthesis