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The compound is best known as an inhibitor of nicotinamide Nmethyltransferase (NNMT), an enzyme implicated in adipose tissue energy handling and nicotinamide adenine dinucleotide (NAD+) turnover.

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Apolipoprotein E (APOE) is a multifunctional protein expressed by various cell types, including hepatocytes, adipocytes, immune cells of the myeloid lineage, vascular smooth muscle cells, astrocytes, etc

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