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Glutathione peroxidase (GPx) family and superoxide dismutase (SOD) family are antioxidant enzymes, that can protect the cells from oxidative damage [70]

Dendrimer brain uptake and targeted therapy for brain injury in a large animal model of hypothermic circulatory arrest

However, the therapeutic utility of doxorubicin is undermined by its dose-dependent cardiotoxicity, possibly arising as a result of futile redox cycling, with NADH dehydrogenase within the mitochondria proposed as the most likely site of anthracycline reduction 9,10

Bedlington Terriers, Doberman Pinschers and Labrador Retrievers are susceptible to copper storage disease, while toy breeds such as Maltese, Yorkshire Terriers and Cavalier King Charles Spaniels are often born with liver shunt anomalies