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The ARTs have resulted in successful fertilization, pregnancy, and live birth of offspring in humans (Marzano et al., 2020) and animals (Morgan et al., 2020) without the use of seminal plasma

This was noted in counteraction of rat occlusion/occlusion-like syndromes as an activation of the collateral-rescuing vascular pathway [1]

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Precision medicine approaches may eventually allow individualized diagnostic strategies based on genetic, biomarker, and clinical risk factors
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