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Experimental models of depression have demonstrated a reduction in the number and density of GFAP-positive astrocytes in the prefrontal cortex (PFC), locus coeruleus, hippocampus, and amygdala, alongside changes in their morphology and functionality (Zhang et al., 2008

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5.6 Neuroprotective effect Polyphenols are increasingly recognized for their neuroprotective properties, primarily attributed to their potent antioxidant and anti-inflammatory activities (377, 403)