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For a substance or method to be added to the List, it must be determined that it meets at least two of the following three criteria: It has the potential to enhance or enhances sport performance It represents an actual or potential health risk to athletes It violates the spirit of sport The full 2024 List was published on 28 September 2023, giving more than three months notice to athletes, their entourage, and other stakeholders, enabling them to acquaint themselves with any modifications

Most patients do their B12 shots in-clinic since they're quick and cheap

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Its selectivity for NNMT (IC50 values in the low micromolar range) means it increases NAD+ by preserving nicotinamide availability rather than directly supplementing NAD+ precursors

This approach costs less overall and allows more precise management of each component