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The unique binding sites of isatuximab and daratumumab may explain their differential in vitro abilities to inhibit the CD38 enzymatic activity and to induce different structural changes within the CD38 molecule upon binding

Acknowledgements The study was funded by InBrain Pharma, France, a spin-off of the research academic team UMR-S 1172 (University of Lille, INSERM, University Hospital of Lille), which delegated the promotion of the study to the University Hospital of Lille, France

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These effects may include: Increased fat oxidation Improved energy balance Reduced fat accumulation However, more long-term research is required to confirm these benefits