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A recent meta-analysis that included thirty-one studies reported that patients who received metformin had a significantly higher risk of vitamin B 12 deficiency in comparison with diabetic patients not taking metformin, and significantly lower serum vitamin B 12 concentrations which depended on dose and duration of treatment [84]
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In alcoholic liver diseases, the role of the gut-brain axis should also be taken into account since anxiety and depression are usually coupled with excessive alcohol consumption (98)
That leaves huge holes in our understanding of acute and long-term harms, particularly for fertility
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