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Arenas et al

NurwantoroNRizqiatiHKarimyMFWahyuningsihRFauziahFRAnandaNSDet al., eds

This differential tissue regulation of these enzymes results in increased BCAAs in adipose tissue, a decrease in liver BCAAs and no change in skeletal muscle

The OCTN2 carnitine transporter mediates high-affinity carnitine transport Defective OCTN2 activity reduces carnitine levels and impairs fatty acid oxidation Missense mutations in OCTN2 define the function of selected transporter domains Defects in carnitine biosynthesis do not reduce carnitine levels Acknowledgments This work was supported in part by NIH grant DK 53824
Therefore, several readily-made dietary supplements, including LAC, have been tested as potential treatments for BD with mitochondrial regulatory functions (61, 62)

A 2015 clinical trial (N = 336 LOE2b) showed that LC supplementation ameliorated chemotherapy-induced peripheral neuropathy and cancer-related fatigue symptoms in Chinese cancer patients [75]
