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This depends on how severe the deficiency is and how well the patient responds to treatment

The combination of the amylin analogue pramlintide and the recombinant human leptin metreleptin caused significant weight reductions ( - 11.5kg) in comparison with monotherapy in a 24-week phase 2 clinical trial [248]

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[DOI] [PubMed] [Google Scholar] 73.Steiner J.M

Nursing There is no evidence that this drug is excreted in human milk

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