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Overexpression of NLRP3 increases IL-4 levels and decreases the M1/M2 ratio, whereas silencing NLRP3 suppresses IL-4 secretion and increases the M1/M2 ratio

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Elimination occurs primarily through renal excretion of metabolites, with the peptide and its fragments detectable in urine for up to 4 days following administration despite plasma clearance within hours

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Additionally, 0.9% saline was administered to the WT group once daily for three months