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Lastly, there were no Notch-dependent differences in metabolites resulting from redox imbalance, including GSH/GSSG ratio, NAD+ or NADP+ levels (Appendix Fig

Although the US Food and Drug Administrationapproved indications for tranexamic acid include treatment of patients with menorrhagia and reduction or prevention of hemorrhage in patients with hemophilia undergoing a tooth extraction, the potential efficacy of tranexamic acid in the treatment of melasma has been consistently reported since the 1980s

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Therefore, the role of oxidative stress in cell death has not been unequivocally established, and the mechanisms by which oxidative stress induces distinct cell death signaling pathways are also elusive