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ASXL1 EBM -dependent recruitment of BRD4 to ASXL1 targets Frameshift variants of ASXL1, including truncated mutants comprising amino acids 1-591 and 1-645 (ASXL1 1-591 and ASXL1 1-645 ), have been linked to various cancers, most frequently to myeloid malignancies and clonal hematopoiesis 31,32,33,34,35 (Fig