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In the case of suspected cobalt hypersensitivity, an intradermal test dose should be administered because anaphylactic shock and death have followed parenteral administration of cyanocobalamin

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J Endocrinol 160 : 247255 Norrelund H et al

Potential Risks and Precautions Certain individuals should use caution with B12 shots

[5] You are encouraged to report negative side effects of prescription drugs to the FDA