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Abstract Hepatic steatosis is the main characteristic of some liver metabolism diseases

Statements Author contributions FL and XDH performed the literature search wrote and revised the paper

While traditional treatmentssuch as pain medications, physical therapy, and spinal surgeryfocus on symptom management or structural adjustments, they often fail to address underlying tissue damage

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It is highly likely that many other natural compounds used, especially in traditional Asian medicine, could have similar effects, although clinical data supporting these are lacking [117119]

The more direct published evidence currently available concerns VEGFR2 expression, VEGFR2-Akt-eNOS signaling, and Src-Cav-1-eNOS pathway activation rather than the complete transcriptional-to-secretory VEGF sequence