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GPXs GPXs, discovered in 1957, comprise an enzyme family with eight members (GPX1-GPX8) characterized by similar sequences, biochemical functions and a catalytic domain consisting of selenocysteine/cysteine, glutamine and tryptophan [10,11]

Mechanistically, we reveal that VRK2 inhibition disrupts endoplasmic reticulum (ER)-to-Golgi trafficking of SLC7A11, consequently diminishing GSH biosynthesis and predisposing PC cells to ferroptosis

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National Library of Medicine Medical Subject Headings (MeSH) EC 2.5.1.18 Glutathione Vs Vitamic C Preparation of GST Fusion Proteins How Does Glutathione Work GST Gene Fusion System Handbook Archived 2008-12-05 at the Wayback Machine