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Despite advances in chemotherapy, radiotherapy, and targeted therapies, challenges such as poor drug accumulation, systemic toxicity, and multidrug resistance persist, partly due to elevated intracellular GSH levels that neutralize reactive therapeutics and reduce treatment response

Additionally, the popularity of TK modelling has thrived due to the possibility of quantitatively estimate TK and toxicodynamic (TD) variability used in risk assessment decision-making (Kreutz et al

In addition, tumor-on-a-chip integrates tumor and stromal cells instead of healthy tissue cells, to mimic invasive tumor behaviour and TME dynamics (Li et al., 2023a

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AMB Express 7:107 Zhang JJ, Chen H, Chen MJ, Wang H, Wang Q, Song XX, Hao HB, Feng ZY (2018) Kojic acid-mediated damage responses induce mycelial regeneration in the basidiomycete Hypsizygus marmoreus