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[1] Because intrinsic-factor-dependent uptake in the distal ileum can be absent in conditions such as autoimmune gastritis, pancreatic insufficiency, or bariatric surgery, the intramuscular or subcutaneous route bypasses gastrointestinal barriers and reliably restores serum concentrations

doi: 10.1111/dom.13641 23

Their antiinflammatory effects are mediated through the inhibition of proinflammatory pathways like NFB and MAPK, reducing the production of cytokines such as IL1 and TNF (Buzdar et al

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10.1105/tpc.7.2.173 Plant Cell 91 ParkC

Thus, detecting vitamin B12 deficiency and treating it is vital in preventing such complications