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16 Common gene variants within this multienzyme complex are likely to modulate cellular response to UVR through alteration of the ability of these enzymes to utilize folate and translocate to the nucleus

10.1073/pnas.1323599111 PNAS 63 KaminskiH.AndradeF

The enzyme carbamoyl phosphate synthetase II (CPSII) uses glutamine to synthesize carbamoyl phosphate, a precursor for pyrimidine production

These disparities substantially limit data integration and model generalizability across research centers

Mutant glucocerebrosidase impairs -synuclein degradation by blockade of chaperone-mediated autophagy

A significant dose-response relationship between ibuprofen intake (tablets/week) and reduced PD risk was found