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Neuroimaging biomarkers also offer substantial predictive value, for example, reduced DAT uptake on PET scans can detect dopaminergic deficits 510 years before clinical symptom onset and help predict conversion to manifest PD [248, 249]

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Usp14 down-regulation corrects sleep and circadian dysfunction of a Drosophila model of Parkinsons disease, suggesting it may modulate neurodegeneration-related disruptions in biological time (Favaro et al., 2024)

Genetic and Metabolomic Dissection of the Ergothioneine and Selenoneine Biosynthetic Pathway in the Fission Yeast, S

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Briefly, cells were seeded onto 24-well chamber slides, rinsed with ice-cold PBS and methanol at 20 C for 10 min, and then permeabilized with 0.1% Triton X-100