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This effect underlies the reports of ascorbate toxicity in mammalian cell cultures and the low (or lack of) ascorbate addition to culture media [3], [8], [27]

10.1021/bi900895b 5 BoermaJ

Schnabl B, Brenner DA


Hosseinzadeh H, Tafaghodi M, Mosavi MJ, Taghiabadi E

Studies have shown that ACh can reduce the transient calcium amplitude of muscarinic ACh receptors to regulate the levels of calcium and iron, thereby alleviating oxidative stress injury (41)
