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Sirtuins, caloric restriction, and lifespan extension Deacetylation of histones is needed for silencing gene expression, and a specific group of histone NAD-dependent deacetylases, the sirtuins, has been associated with longevity

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My recommendation for best results is to clean up your diet, exercise 3 days a week or take daily walks, drink plenty of water, and look into fiber, protein, and electrolyte supplements

[2] Demarquoy C, Demarquoy J

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