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This meant that there was a large therapeutic window, and a wide range of the agents efficacy (gng), at any stage of the noxious course

185 Besides, other MTHFD2 inhibitors have been reported, including DS18561882 and LY345899 in a substrate-based manner, and treatments based on them decrease cellular NADPH/NADP + ratio, increase cellular ROS levels, and impair tumorigenesis and metastasis

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