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Indeed, the bell curve predicts that such an event is a practical impossibility

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For instance, doxorubicin, a topoisomerase inhibitor, induces DNA damage in cancer cells by interfering with topoisomerases and unwinding supercoiled DNA 24

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10.1038/nature03988 234 PavekP

Careful selection of the antibodies for detection and/or targeting is therefore of key importance for better understanding and clinical exploitation of CA IX