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If well tolerated with no concerns, consider either maintaining 0.1 mg once daily or increasing to 0.125 mg once daily based on response

Changing the dose or stopping the medication too quickly can cause withdrawal symptoms that can be mild to severe

What the clinical trial evidence shows Mounjaro (tirzepatide) ~22.5% average body weight lost at 72 weeks ( SURMOUNT-1, 15mg) Wegovy (semaglutide) ~14.9% average body weight lost at 68 weeks ( STEP-1 , 2.4mg) Saxenda / Nevolat (liraglutide) ~5-8% average body weight lost at 56 weeks ( SCALE trial ) For context, prior to GLP-1 medications, the most effective non-surgical weight loss intervention available was a combination of intensive lifestyle modification and Orlistat , which typically produces 5 to 8% weight loss

Bloating is noticeably better

Vitamin B12 plays a role in DNA synthesis and red blood cell formation