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Next, scaffolding analysis was carried out and it was found that R1 of compound 3f was substituted with 3-OCH3 and 4-OH on the A ring, and R1 of compounds 3m and 3n was substituted with 3-OCH3 and 4-OH on both the A and B rings

Given that LCL-161 is currently undergoing phase 2 clinical trials for MM, these findings suggest that SMs may offer additional clinical benefits by mitigating bone degradation in myeloma patients (8)

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however, GSH levels in liver, lung, pancreas, erythrocytes, and plasma of these animals are 916% of that wild type littermates, and cysteine levels are 9, 35, and 40% of that of wild type mice in kidney, pancreas, and plasma, respectively, but are unchanged in the liver and erythrocytes (Yang et al., 2002)

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Bile acids trigger GLP-1 release predominantly by accessing basolaterally located G protein-coupled bile acid receptors