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Limitations in Clinical Evidence and Trial Design The current orthopaedic literature on peptides is dominated by animal models, small prospective cohorts, and case series, with very limited RCTs

Nicotinamide Adenine Dinucleotide (NAD+) is a naturally occurring molecule found in every cell of the body

Formulations: Standard Dose: 5mg BPC-157 + 5mg TB-500 (2mL vial 2.5mg/mL each)

AOD-9604 Research Protocols & Administration Dosing in Published Research Research investigations have employed diverse AOD-9604 doses across species and administration routes: Rodent studies: 250-500 mcg/kg orally or intraperitoneally was most common for obesity research Rabbit models: 0.25 mg per joint for osteoarthritis studies (intra-articular injection) Pig pharmacokinetic studies: 1.5 mg/kg IV and 2 mg/kg oral for metabolism characterization Human clinical trials: Oral doses of 0.25-10 mg daily

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Coffee enemas are not well accepted by the conventional medical community (3) and we dont have as much data or information suggesting they can be beneficial compared to some of the other topics we will be discussing today