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The source of the T-cells in progressive MS lesions is unclear given that the BBB remains largely intact despite the enriched lymphocytic trafficking [72, 73]

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2019;83:e00012-19

In experimental studies, formation of complexes of cellular antigen with antibody resulted in activation of dendritic cells, facilitation of cross-presentation of antigens to tumor-specific CD 8 + T cells and inhibition of tumor growth Fc receptor-targeted antigen uptake was shown to initiate cross-presentation pathways as an immune regulatory mechanism for effective tumor immunity