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Method accuracy was validated using CRM MESS-3 and DORM-4 (National Research Council of Canada, NRC CNRC) ( n = 3), yielding results of 0.088 0.004 g 1 (MESS-3) and 0.457 0.04 g g 1 (DORM-4), consistent with certified values of 0.091 0.009 g g 1 and 0.412 0.036 g g 1 , with recovery result of 97 and 111%, respectively (Supplementary Table 1)

It inhibits the production of pro-inflammatory cytokines

This process not only benefits to maintain the reducing environment within cells but also regenerates other crucial antioxidants like vitamin C and vitamin E, thereby boosting the cells antioxidant ability (Poladian et al., 2023)

Lewy bodies, primarily composed of misfolded synuclein, aggregate within neurons, disrupting cellular proteostasis and damaging mitochondria, thus promoting neuronal toxicity (Figure 2) [5]

Indeed, downregulation of CAT protein expression was reported in MASH patients as compared to control (Shearn et al