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While obesity is linked to poor sperm quantity and quality and lower chance of successful pregnancy and birth, weight loss in obese men has been shown to rapidly improve sperm numbers, motility, morphology, and DNA fragmentation rate

c-Met is overexpressed in multiple human cancers including gastric, lung, colorectal, and hepatocellular carcinoma, where aberrant HGF/c-Met signaling drives tumor growth, invasion, and metastasis
Peptides that boost growth hormone without local tissue effects do not qualify either

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Regulation of insulin sensitivity by serine/threonine phosphorylation of insulin receptor substrate proteins IRS1 and IRS2
