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Diabetes associated cell stress and dysfunction role of mitochondrial and non-mitochondrial ROS production and activity P

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H., Eu, J

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The nuclear respiratory factors (Nrf1 and Nrf2) that initiate the transcription of genes linked to mitochondrial biogenesis are co-activated by SIRT1 through the activation and deacetylation of peroxisome proliferator-activated receptor gamma coactivator 1 alpha (PGC-1) (Scarpulla, 2011), a master regulator of mitochondrial biogenesis

Martelli, L