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This reduction may lead to impaired detoxification of H 2 S, resulting in elevated levels of the gas in the colon, which destabilizes the protective mucosal layer and promotes bacterial interactions with epithelial cells [136]

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These models have been used to evaluate: soft-tissue and connective-tissue injury responses tendon and ligament healing environments experimentally created muscle injuries gastrointestinal integrity and inflammatory responses nerve-lesion and neuroinflammatory pathways Outcomes vary depending on dosage, timing, delivery route, and the nature of the injury model