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doi: 10.1007/s10384-016-0488-3 327 DongNXuBWangBChuLTangX

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Some people experience a significant decrease in their symptoms, while others may find only slight improvement

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Tumors simultaneously rewire antioxidantsactivating NRF2 and elevating GSH/thioredoxin systemscreating a narrow therapeutic window in which pushing ROS beyond buffering capacity triggers apoptosis or ferroptosis, whereas indiscriminate scavenging blunts therapy and fosters resistance (Reczek and Chandel 2017)