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Metformin is a popular drug used to target oxphos throughout these studies, and while it is FDA approved for management of diabetes, it is known for having many off-target effects

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The estrogen-related receptor alpha (ERRalpha) functions in PPARgamma coactivator 1alpha (PGC-1alpha)-induced mitochondrial biogenesis

The results established tirzepatide as the most effective anti-obesity medication available at the time of publication

For context, the toxic dose is estimated at roughly 22,500 mg, compared to a typical weekly dose of about 6 mg

Not having enough of it is common, especially for people who dont eat meat, like vegetarians or vegans