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PBMCs were suspended at a concentration of 2.55 10 6 /ml, as the sample amount allowed

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While proteostasis is governed by a network that collectively controls the biogenesis, folding, trafficking, and degradation of proteins present within and outside the cell, metallostasis is likewise controlled by a network of metal sensing, transport, speciation and ultimately trafficking of these finite inorganic resources to a specific task (Figure 1)

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