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Fatty acid oxidation in cell fate determination

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In the resting state, continuous IGF1 stimulation ultimately induced down-regulation of Akt or ERK and Foxo3a activation, thereby inhibiting proliferation and enhancing self-renewal

While passive diffusion was initially proposed as the main absorption route, recent evidence indicates that specific transmembrane transporters including Na-taurocholate cotransporting polypeptide, organic anion-transporting polypeptides, L-type amino acid transporters, and monocarboxylate transporters also facilitate LT4 uptake